It might not be quite what you're looking for, but our group started using Roll20 recently. It has some quirks and is missing some spell data, but it is very customizable and includes online video chat. Think "Google Hangouts meets D&D."
I've used roll20, but I don't find it very useful for non-virtual roleplaying. I'm looking for something that integrates calendaring, drive, etc; meanwhile, video chat is not particularly valuable.
